Search for "diastereoselective domino Knoevenagel–[1,5]-hydride shift cyclization" in Full Text gives 1 result(s) in Beilstein Journal of Organic Chemistry.
Beilstein J. Org. Chem.2014,10, 2594–2602, doi:10.3762/bjoc.10.272
cellular injuries in human neuroblastoma SH-SY5Y cells in the range of those of positive controls.
Keywords: 1,4-benzoxazepine; diastereoselectivedominoKnoevenagel–[1,5]-hydrideshiftcyclization; neuroprotective; tert-amino effect; TDDFT-ECD calculation; Introduction
The 1,4-benzoxazepine structural
neuroprotective condensed 2-phenyl-1,4-benzoxazepines rac-7a,b through the diastereoselectivedominoKnoevenagel–1,5-hydrideshiftcyclization reaction rac-5→rac-7a,b from the readily available 4-aryl-2-phenyl-1,4-benzoxazepine derivative, rac-5 (Scheme 1).
Ring-closure transformations involving C(sp3)–H bond
] or organocatalytic [16][17] reactions and the mechanism of the stereospecific hydride transfer have been recently studied by several research groups. The synthetic potential of the diastereoselectivedominoKnoevenagel–[1,5]-hydrideshiftcyclization reaction was exploited in our present work for the
PDF
Graphical Abstract
Figure 1:
Pharmacologically active derivatives 1–4 containing the 1,4-benzoxazepine moiety or its analogue.